Relationship Between AUC and Volume of Distribution
A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…
Certara2011 年 1 月 26 日
Where Did the 80-125% Bioequivalence Criteria Come From?
Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…
Certara2011 年 1 月 24 日
Generics and Bioequivalence
As the debate about health care in the United States continues forward, the term “generic…
Certara2011 年 1 月 10 日
What are Compartmental Models?
Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…
Certara2011 年 1 月 5 日
What are Drug-drug Interactions Anyway?
A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…
Certara2011 年 1 月 5 日
Trial Designs—Non-inferiority vs. Superiority vs. Equivalence
The primary purpose of a clinical trial is to address a scientific hypothesis. To address…
Certara2011 年 1 月 1 日
Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models
The prediction of drug-drug interactions (DDIs) from in vitro data usually utilizes an average dosing…
Certara2011 年 1 月 1 日
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain
ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…
Certara2011 年 1 月 1 日
