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Certara 推出用于早期和转化药物开发的新 Simcyp™ 发现模拟器

Advances lead optimization, first-in-human dose prediction and formulation development

Princeton, N.J., 2022 年 6 月 28 日: Certara (Nasdaq: CERT), a global leader in biosimulation, today announced the release of Simcyp Discovery Simulator, a new software designed for scientists working in small molecule drug discovery and translational research. Derived from the industry-leading Simcyp Simulator, Simcyp Discovery increases confidence in early-stage development decisions using physiologically-based pharmacokinetic (PBPK) modeling and simulation. 

“We are pleased to offer our new Simcyp Discovery Simulator to help identify and move forward the most promising new drug candidates for further investigation,” said William F. Feehery, Ph.D., CEO of Certara. “The failure rate from preclinical to clinical studies is high with only a third of drugs entering into human testing.  With Simcyp Discovery, scientists can apply PBPK earlier in the development process to better inform critical decisions and reduce risk of drug failure.”

Simcyp Discovery includes PBPK models for mouse, rat, dog, monkey and humans, enabling researchers to predict first-in-human (FIH) pharmacokinetics and understand how investigational drugs may behave before going into clinical trials, a regulatory requirement. The software also supports early formulation simulations and flags potential drug-drug interactions (DDI) with a new static DDI calculator informed by regulatory guidelines from the U.S. Food and Drug Administration, European Medicines Agency, and Japan’s Pharmaceuticals and Medical Devices Agency. Additionally, Simcyp Discovery supports rapid batch processing and screening of drug candidates.

“The role of modeling and simulation in drug discovery and development continues to expand and evolve. At Certara, we are committed to advancing our technology to meet the needs of researchers throughout the entire drug lifecycle,” said Robert Aspbury, Ph.D., president of Simcyp at Certara. “Simcyp Discovery will help improve translational research and impact patient safety and efficacy.”

For more information about Simcyp Discovery, please visit: https://www.certara.com/simcyp-overview/simcyp-discovery/


关于Certara

Certara accelerates medicines using proprietary biosimulation software, technology and services to transform traditional drug discovery and development. 其客户包括超 2,000 家生物制药公司、学术机构和来自 62 个国家的监管机构。

联系人:

Jieun W. Choe
jieun.choe@certara.com

Media Contact

Ariane Lovell
Finn Partners
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David Deuchler
ir@certara.com

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