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ACoP14 2023

ACoP14 2023

We are excited to be presenting at this conference

Workshop: Pre-Meeting Workshop (8 am – 5 pm ET) – Model-Based Meta-Analysis (MBMA): Concepts, Methodologies, and Hands-on Workshop.

Matt Zierhut, VP IDD and Jaap Mandema, CIO

2023 年 11 月 5 日, 星期日 | 8am-5pm

Workshop: Pre-Meeting Workshop (8 am – 5 pm ET) – Simcyp Designer PBPK-QSP Focused Workshop

Tariq Abdulla, Associate Principal Scientist and Frederic Bois, Sr. Sci Advisor and Head of Mechanistic Modeling

Demo: QSP/Simcyp Designer: A graphical editor to seamlessly integrate QSP models with Simcyp Simulator

Booth #3 & 4

Concurrent Session 1B – Moving Boundaries: Towards Virtual Twin Patients in Clinical Trials and Precision Medicine for CNS Disorders.

Hugo Geerts, PhD

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Head of Neuroscience, QSP

Concurrent Session 1B – MIDD V2.0: Integrating Mechanistic Modeling and Artificial Intelligence.

Piet van der Graaf, PharmD, PhD

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高级副总裁,定量系统药理学部

Demo: PMX Pharmacometrics Tools: Tailored for all user levels. Explore our new machine learning model selection feature in Pirana, along with advanced R, Shiny, and R Markdown reporting.

Booth #3 & 4

Demo: QSP Designer/Neuro: Platform offering a powerful tool to predict the effect of amyloid antibodies on biomarkers and side-effects in a clinical Alzheimer population in both trial design and real-world treatment.

Booth #3 & 4

Demo: CODEX Analytics App: Software to enable intuitive exploration and analyses of clinical outcomes databases

Booth #3 & 4

Demo: PMX Pharmacometrics Tools: Tailored for all user levels. Explore our new machine learning model selection feature in Pirana, along with advanced R, Shiny, and R Markdown reporting.

Booth #3 & 4

Demo: PMX Pharmacometrics Tools: Tailored for all user levels. Explore our new machine learning model selection feature in Pirana, along with advanced R, Shiny, and R Markdown reporting.

Booth #3 & 4

Demo: QSP Model of Complement System (CS): Complement pathway in immune defense.

Booth #3 & 4

IsoP Trainee Communication Challenge

Certara Representatives: Suzanne Minton, PhD and Mirjam Trame, Pharm D., PhD

Monday, November 6 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: Dose Guidance for a Novel Combination Therapy to Treat Head and Neck Squamous Cell Carcinoma (HNSCC) for Patients with HRAS/PIK3CA Variants Using a Quantitative Systems Pharmacology (QSP) Model

Jaehee Shim, Douglas Chung, Piet H van der Graaf

Monday, November 6 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: Exploring treatment guidelines for amyloid therapies in Alzheimer’s Disease Using Predictive Quantitative System Pharmacology Modeling

Hugo Geerts, Rachel Rose, Piet van der Graaf

Monday, November 6 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: A population-based approach predicts COVID-19 paediatric immunobridging trial outcomes using a QSP model of Tozinameran mRNA vaccine

Dennis Reddyhoff, Piet H. van der Graaf, Andrzej Kierzek

Monday, November 6 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Population Pharmacokinetic Modeling of Dordaviprone in Healthy Adult Participants and Adult and Pediatric Patients with Solid Tumors.

Laura E. Strong, Shamia Faison, Tim Tippin, Tom Brundage, Odin Naderer, and Ayman Akil
Certara & Chimerix

Monday, November 6 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Evaluation of the Boruta Machine Learning Algorithm for Covariate Selection

Ayman Akil, Vincent Duval, Nathan Teuscher, Floris Fauchet, Anna Largajolli, Ibtissem Rebai

2023 年 11 月 6 日, 星期一 | 7:00 PM

Co-Sponsor International Masquerade Social Event

Demo: QSP/Simcyp Designer: A graphical editor to seamlessly integrate QSP models with Simcyp Simulator.

Booth #3 & 4

Demo: PMX Pharmacometrics Tools: Tailored for all user levels. Explore our new machine learning model selection feature in Pirana, along with advanced R, Shiny, and R Markdown reporting.

Booth #3 & 4

Demo: QSP/Simcyp Designer: A graphical editor to seamlessly integrate QSP models with Simcyp Simulator.

Booth #3 & 4

Demo: Vachette – Discover a new and innovative method for visualizing and communicating models with covariate effects made available within the ‘vachette’ R package.

Booth #3 & 4

Session: Application of PBPK model in predicting TP-DI with cytokine modulators

Xian Pan

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Associate Principal Scientist

Demo: PMX Pharmacometrics Tools: Tailored for all user levels. Explore our new machine learning model selection feature in Pirana, along with advanced R, Shiny, and R Markdown reporting.

Booth #3 & 4

Session: Predicting Disease Activity Scores in Inflammatory Bowel Disease by Connecting Simulated Tissue Biomarkers of a Virtual Population to Clinical Biomarkers and Outcomes Using a Novel Algorithm

Doug Chung

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Research Scientist, QSP

Session: Roller Coaster 1

Co Chair: Piet van der Graaf, PharmD, PhD

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高级副总裁,定量系统药理学部

Demo: QSP model of Irritable Bowel Disease (IBD): Auto-immune disease of digestive track.

Booth #3 & 4

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: The interaction of core modules as a basis for elucidating network behavior determining Parkinson’s disease pathogenesis

Suruchi Bakshi

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Principal Scientist QSP

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: Predicting the impact of Haemodialysis with Simcyp Designer

Tariq Abdulla

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Associate Principal Scientist

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: A Quantitative Systems Pharmacology (QSP) Model to Investigate the Efficacy of a Novel Enzyme Replacement Therapy for Classical Homocystinuria (HCU)

Robert Mines, Douglas Chung, Maryam Khalifa, Piet H van der Graaf

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Poster Presentation: NPSA: Nonparametric Simulated Annealing for Global Optimization

Ron Chung

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Research Scientist

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Population Pharmacokinetics Analysis of Bardoxolone Methyl in Healthy Subjects and Subjects with Chronic Kidney Diseases.

Scott M. Hynes, Hamim Zahir, Aparna Shinde, Yu-Wei Lin, Laura Strong, Mayumi Hasegawa, William Copalu, and Nathan Teuscher. Reata Pharmaceuticals & Certara

Wednesday, November 8 | Open to view: 7:00 – 9:00 AM; 12:00 – 1:30 PM

Pharmacometric Model to Describe the Relationship between Bardoxolone Methyl Exposure and eGFR Changes in Patients with Chronic Kidney Disease at Risk of Rapid Progression.

Scott M. Hynes, Hamim Zahir, Aparna Shinde, Laura Strong, Nathan Teuscher, William Copalu, and Marc Pfister
Reata Pharmaceuticals & Certara

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